Nineteen of Medvedev's twenty-one titles have been achieved on hard surfaces
A revitalized Medvedev won his first title for 882 days with victory over Corentin Moutet in the tournament title decider.
The Russian, a former top-ranked player, has experienced a challenging period, winning just one win at the big events and undergoing a setback at the American major.
His varied form on the tennis tour - and difficulties with his serving in specific - resulted in him exiting of the world's top 10 and finally parting ways with former coach his previous coach.
Currently training with his coach and his other coach, Medvedev has steadily improved in the recent weeks - peaking in a hard-fought 7-5 4-6 6-3 victory over Frenchman Moutet.
This marks his maiden title after the Rome competition and first on a hard surface after March of that year.
Victory also means the Russian has won 21 victories at 21 distinct competitions.
"It's the first time I'm at a competition with my both daughters at once, so to secure a trophy is really nice," said world number 14 the champion.
"This championship is in tribute of my younger daughter my daughter, because the first title I achieved when my older daughter her name was born was for her."
Medvedev, the past champion, had been defeated in his last six title deciders, comprising in Halle earlier this year.
The player's defensive approach and frequent reactions on court had prompted observers to question if his skill to compete at the elite level was concluded.
However the 29-year-old has made changes in the past month, striving to approach the net and play assertively, reinforced by an improved serving game.
He fought back from a disadvantage in the opening set against the challenging Moutet, securing four of the concluding five games to gain the advantage.
The competitors swapped break points in the middle set before the Frenchman, bidding for his initial ATP Tour championship, seized the initiative to create a final set.
He saved four early chances in a tight final set before the Russian secured a break to that score to serve for the match.
Suitably, Medvedev clinched victory with a point at the net area, with his opponent failing to control a shot after a lengthy match.